Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury
نویسندگان
چکیده
منابع مشابه
Protein tyrosine phosphatase 1B deficiency in podocytes protects against hyperglycemia-induced renal injury
Diabetic nephropathy is one of the most devastating complications of diabetes, and growing evidence implicates podocyte dysfunction in disease pathogenesis. Protein tyrosine phosphatase 1B (PTP1B; encoded by PTPN1) is an established metabolic regulator in vivo but its metabolic functions in podocytes remains unexplored. To that end, we generated podocyte-specific PTP1B knockout (pod-PTP1B KO) m...
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ژورنال
عنوان ژورنال: Metabolism
سال: 2017
ISSN: 0026-0495
DOI: 10.1016/j.metabol.2017.07.009